Triazolopyridines as thrombin inhibitors for the treatment of thromboembolic diseases

Compound of the formula

• in which
• R1 represents a group of the formula
• where * is the point of attachment to the carbonyl group,
• X represents an oxygen atom, a sulphur atom or CH—R6,
• where
• R6 represents hydrogen or hydroxy,
• R2 represents hydrogen, aminocarbonyl, C1-C6-alkyl, C3-C6-cycloalkyl or phenyl,
• where alkyl and cycloalkyl may be substituted by a substituent selected from the group consisting of hydroxy, methoxy, cyano, hydroxycarbonyl, aminocarbonyl, methylsulphonyl, difluoromethoxy and trifluoromethoxy,
• or
• where alkyl and cycloalkyl may be substituted by 1 to 3 fluorine substituents,
• R3 represents hydrogen or C1-C4-alkyl,
• or
• R2 and R3 together with the carbon atom to which they are attached form a cyclobutyl ring, cyclobutyl ring or cyclopentyl ring,
• where the cyclobutyl ring and the cyclopentyl ring may be substituted by a hydroxy substituent,
• R4 represents hydrogen or C1-C6-alkyl,
• where alkyl may be substituted by a hydroxy substituent,
• or
• where alkyl may be substituted by 1 to 3 fluorine substituents,
• R5 represents C1-C4-alkyl,
• or
• R4 and R5 together with the carbon atom to which they are attached form a cyclopropyl ring, cyclobutyl ring or cyclopentyl ring,
• where the cyclobutyl ring and the cyclopentyl ring may be substituted by a hydroxy substituent,
• R7 represents hydrogen or C1-C6-alkyl,
• where alkyl may be substituted by one substituent selected from the group consisting of cyano, hydroxy and methoxy,
• or
• where alkyl may be substituted by 1 to 3 fluorine substituents,
• R8 represents hydrogen,
• R9 represents hydrogen or C1-C6-alkyl,
• where alkyl may be substituted by one substituent selected from the group consisting of hydroxy and cyano,
• or
• where alkyl may be substituted by 1 to 3 fluorine substituents,
• R10 represents hydrogen,
• R11 represents C1-C4-alkyl,
• where alkyl may be substituted by a hydroxy substituent,
• R12 represents hydrogen or C1-C4-alkyl,
• or
• R11 and R12 together with the carbon atom to which they are attached form a cyclopropyl ring, cyclobutyl ring or cyclopentyl ring,
• where the cyclobutyl ring and the cyclopentyl ring may be substituted by a hydroxy substituent,
• R13 represents hydroxymethyl or hydroxyethyl,
• R14 represents methoxy or ethoxy,
• where methoxy and ethoxy may be substituted by 1 to 3 substituents selected from the group consisting of deuterium and fluorine,
• and
• R15 represents hydrogen, methyl or fluoromethyl,
• or one of the salts thereof, solvates thereof or solvates of the salts thereof.