Heterocyclic derivates

A compound of formula (I),

• wherein
• B is a fused 6,5- or 6,6-heteroaromatic bicyclic ring, containing N and, optionally, one or two additional heteroatoms independently selected from N, O and S, which is optionally mono-, di or tri-substituted with a substituent selected from alkyl, alkoxy, OH, halo, CN, COOR8, CONR8R9, CF3 and NR8R9;
• wherein when B is a fused 6,5-heteroaromatic bicyclic ring, it is linked to —CONH—(CH2)— via its 6-membered ring component;
• W, X, Y and Z are independently selected from C, N, O and S, such that the ring containing W, X, Y and Z is a five membered aromatic heterocycle;
• wherein,
• R5, R6 and R7 are independently absent or independently selected from H, alkyl, halo, OH, aryl, heteroaryl, —NR8R9, CN, COOR8, CONR8R9, —NR8COR9, CF3, and R16;
• wherein at least one of R5, R6 and R7 is present and is independently selected from alkyl, halo, OH, aryl, heteroaryl, —NR8R9, CN, COOR8, CONR8R9, —NR8COR9, CF3 and R16;
• A is selected from aryl and heteroaryl;
• R8 and R9 are independently selected from H and alkyl;
• R16 is a carbon-containing 3-, 4-, 5- or 6-membered monocyclic ring system which may be aromatic, saturated or unsaturated non-aromatic and which may optionally contain 1, 2, 3 or 4 heteroatoms selected from N, O and S, wherein the ring system R16 is in turn optionally substituted with substituents selected from alkyl and oxo;
• alkyl is a linear saturated hydrocarbon having up to 10 carbon atoms (C1-C10) or a branched saturated hydrocarbon of between 3 and 10 carbon atoms (C3-C10), optionally substituted with 1 or 2 substituents independently selected from (C1-C6)alkoxy, OH, CN, CF3, COOR10, CONR10R11, fluoro and NR10R11;
• alkoxy is a linear O-linked hydrocarbon of between 1 and 6 carbon atoms (C1-C6) or a branched O-linked hydrocarbon of between 3 and 6 carbon atoms (C3-C6), optionally substituted with 1 or 2 substituents independently selected from OH, CN, CF3, COOR10, CONR10R11, fluoro and NR10R11;
• aryl is phenyl, biphenyl or naphthyl, optionally substituted with 1, 2 or 3 substituents independently selected from alkyl, alkoxy, methylenedioxy, ethylenedioxy, OH, halo, CN, morpholinyl, piperidinyl, heteroaryl, —(CH2)0-3—O-heteroaryl, arylb, —O-arylb, —(CH2)1-3-arylb, —(CH2)1-3-heteroaryl, —COOR10, —CONR10R11, —(CH2)1-3—NR14R15, CF3 and —NR10R11;
• arylb is phenyl, biphenyl or naphthyl, optionally substituted with 1, 2 or 3 substituents independently selected from alkyl, alkoxy, OH, halo, CN, morpholinyl, piperidinyl, —COOR10, —CONR10R11, CF3 and NR10R11;
• heteroaryl is a 5, 6, 9 or 10 membered mono- or bi-cyclic aromatic ring, containing, where possible, 1, 2 or 3 ring members independently selected from N, NR8, S and O, optionally substituted with 1, 2 or 3 substituents independently selected from alkyl, alkoxy, OH, OCF3, halo, CN, aryl, morpholinyl, piperidinyl, —(CH2)1-3-aryl, heteroarylb, —COOR10, —CONR10R11, CF3 and —NR10R11;
• heteroarylb is a 5, 6, 9 or 10 membered mono- or bi-cyclic aromatic ring, containing, where possible, 1, 2 or 3 ring members independently selected from N, NR8, S and O;
• wherein heteroarylb may be optionally substituted with 1, 2 or 3 substituents independently selected from alkyl, alkoxy, OH, halo, CN, morpholinyl, piperidinyl, aryl, —(CH2)1-3-aryl, —COOR10, —CONR10R11, CF3 and NR10R11;
• R10 and R11 are independently selected from H and alkyl or R10 and R11 together with the nitrogen atom to which they are attached form a carbon-containing 4-, 5-, 6- or 7-membered heterocylic ring which may be saturated or unsaturated with 1 or 2 double bonds and which may be optionally mono- or di-substituted with substituents selected from oxo, alkyl, alkoxy, OH, F and CF3;
• R14 and R15 are independently selected from alkyl, arylb and heteroarylb;
• or R14 and R15 together with the nitrogen atom to which they are attached form a carbon-containing 4-, 5-, 6- or 7-membered heterocylic ring which may be saturated or unsaturated with 1 or 2 double bonds, and optionally may be oxo substituted;
• or a tautomer, isomer, stereoisomer (including enantiomer, diastereoisomer and racemic or scalemic mixture thereof), pharmaceutically acceptable salt or solvate thereof;
• wherein the compound of formula (I) is not: