Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof

A compound of formula (I), or a tautomer, mesomer, racemate, enantiomer, or diastereomer thereof, or mixture thereof, or a pharmaceutically acceptable salt thereof:

• wherein:
• ring A is cycloalkyl, wherein the cycloalkyl is optionally substituted with one or more groups selected from the group consisting of halogen, cyano, nitro, amino, hydroxy, oxo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxyl and alkoxycarbonyl;
• W1 is N or CRa;
• W2 is N or CRb;
• W3 is N or CRc;
• Ra, Rb and Rc are each independently selected from the group consisting of hydrogen, halogen, cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —OR4, —S(O)mR4, —C(O)R4, —C(O)OR4, —C(O)NR5R6, —NR5R6 and —NR5C(O)R6, wherein the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each independently optionally substituted with one or more groups selected from the group consisting of halogen, cyano, nitro, oxo, alkyl, haloalkyl, hydroxyalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —OR4, —S(O)mR4, —C(O)R4, —C(O)OR4, —C(O)NR5R6, —NR5R6 and —NR5C(O)R6;
• R1 is hydrogen or alkyl;
• R2 and R3 are each independently selected from the group consisting of hydrogen, halogen, cyano, nitro, alkyl, haloalkyl and hydroxyalkyl;
• R4 is selected from the group consisting of hydrogen, alkyl, halogen, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each independently optionally substituted with one or more groups selected from the group consisting of halogen, cyano, nitro, hydroxy, oxo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxyl, alkoxycarbonyl, —C(O)NR5R6, —NR5R6 and —NR5C(O)R6;
• R5 and R6 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each independently optionally substituted with one or more groups selected from the group consisting of halogen, cyano, nitro, amino, hydroxy, oxo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxyl and alkoxycarbonyl;
• and
• m is 0, 1, or 2.