Histone demethylase inhibitors
AssigneeQuanticel Pharmaceuticals, Inc.
InventorsYoung K. Chen, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal
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Abstract
The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase enzymes. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as pancreatic cancer, prostate cancer, breast cancer, bladder cancer, lung cancer, gastric cancer, leukemia and/or melanoma and the like.
Claims31
A compound having the structure of Formula (Ic),
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is hydrogen, halogen, —OH, —OR5, —N(R5)2, alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl;
- R2 is alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl;
- R3 is hydrogen;
- R4 is hydrogen, C1-C4alkyl, C1-C4alkene, C1-C4alkyne, halogen, or —CN;
- and
- each R5 is independently hydrogen, alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, carbocyclylalkyl, heterocyclylalkyl, aralkyl, or heteroarylalkyl.
Dependencies are inferred from the claim text.