Therapeutic compounds

A compound of formula IIIe

• wherein
• A1 is CH, C—Z3, or nitrogen;
• A2 is CH or nitrogen;
• R1 is 6-12 membered aryl, 5-12 membered heteroaryl, or 3-12 membered heterocycle, wherein any 6-12 membered aryl, 5-12 membered heteroaryl, or 3-12 membered heterocycle of R1 is optionally substituted with 1, 2, 3, 4 or 5 Z4 groups, wherein the Z4 groups are the same or different;
• each R3a and R3b is independently H or (C1-C3)alkyl;
• Z1 is 6-12 membered aryl, 5-14 membered heteroaryl, or 3-14 membered heterocycle, wherein any 6-12 membered aryl, 5-14 membered heteroaryl, or 3-14 membered heterocycle of Z1 is optionally substituted with 1, 2, 3, 4 or 5 Z1a or Z1b, wherein the Z1a and Z1b groups are the same or different;
• each Z1a is independently (C3-C7)carbocycle, 5-12 membered heteroaryl, 3-12 membered heterocycle, halogen, —CN, —ORn1, —OC(O)Rp1, —OC(O)NRq1Rr1, —SRn1, —S(O)Rp1, —S(O)2H, —S(O)2Rp1, —S(O)2NRq1Rr1, —NRq1Rr1, —NRn1CORp1, —NRn1CO2Rp1, —NRn1CONRq1Rr1, —NRn1S(O)2Rp1, —NRn1S(O)2ORp1, —NRn1S(O)2NRq1Rr1, —C(O)Rn1, —C(O)ORn1, —C(O)NRq1Rr1 and —S(O)2NRn1CORp1, wherein any (C3-C7)carbocycle, 5-12 membered heteroaryl and 3-12 membered heterocycle of Z1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c or Z1d groups, wherein the Z1c and Z1d groups are the same or different;
• each Z1b is independently (C1-C8)alkyl optionally substituted with 1, 2, 3, 4 or 5 halogen, which are the same or different;
• each Z1c is independently halogen, —CN, —OH, —NH2, —C(O)NRq2Rr2, or (C1-C8)heteroalkyl;
• each Z1d is independently (C1-C8)alkyl or (C1-C8)haloalkyl;
• each Rn1 is independently H, (C1-C8)alkyl, (C3-C7)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic-heteroaryl, wherein any (C3-C7)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic-heteroaryl of Rn1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c or Z1d groups, wherein the Z1c and Z1d groups are the same or different, and wherein any (C1-C8)alkyl of Rn1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c groups, wherein the Z1c groups are the same or different;
• each Rp1 is independently (C1-C8)alkyl, (C3-C7)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic-heteroaryl, wherein any (C3-C7)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic-heteroaryl of Rp1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c or Z1d groups, wherein the Z1c and Z1d groups are the same or different, and wherein any (C1-C8)alkyl of Rp1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c groups, wherein the Z1c groups are the same or different;
• each Rq1 and Rr1 is independently H, (C1-C8)alkyl, (C3-C8)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic-heteroaryl, wherein any (C3-C7)carbocycle, 3-7 membered heterocycle, or 5-6 membered monocyclic-heteroaryl of Rq1 or Rr1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c or Z1d groups, wherein the Z1c and Z1d groups are the same or different, and wherein any (C1-C8)alkyl of Rq1 or Rr1 is optionally substituted with 1, 2, 3, 4 or 5 Z1c groups, wherein the Z1c groups are the same or different, or Rq1 and Rr1 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4 or 5 Z1c or Z1d groups, wherein the Z1c and Z1d groups are the same or different;
• each Rq2 and Rr2 is independently H, (C1-C8)alkyl, (C3-C7)carbocycle, or Rq2 and Rr2 together with the nitrogen to which they are attached form a 5, 6, or 7-membered heterocycle;
• Z2 is (C2-C8)alkenyl, (C2-C8)alkynyl, 6-12 membered aryl, 5-12 membered C-linked-heteroaryl, 3-12 membered C-linked-heterocycle, —C(O)Rn3, or —C(O)NRq3Rr3, wherein any 6-12 membered aryl, 5-12 membered C-linked-heteroaryl, or 3-12 membered C-linked-heterocycle of Z2 is optionally substituted with 1, 2, 3, 4 or 5 Z2b or Z2c groups, wherein the Z2b and Z2c groups are the same or different, and wherein any (C2-C8)alkenyl or (C2-C8)alkynyl of Z2 is optionally substituted with 1, 2, 3, 4, or 5 Z2c groups, wherein the Z2c groups are the same or different;
• each Rn3 is independently H or (C1-C4)alkyl;
• each Rq3 and Rr3 is independently H or (C1-C4)alkyl;
• each Z2b is independently oxo, (C1-C4)alkyl, (C1-C4)heteroalkyl or (C1-C4)haloalkyl;
• each Z2c is independently oxo, halogen, —CN;
• —ORn4, —OC(O)Rp4, —OC(O)NRq4Rr4, —SRn4, S(O)Rp4, —S(O)2H, —S(O)2Rp4, —S(O)2NRq4Rr4, —NRq4Rr4, —NRn4CORp4, —NRn4CO2Rp4, —NRn4CONRq4Rr4, —NRn4(O)2Rp4, —NRn4S(O)2ORp4, —NRn4S(O)2NRq4Rr4, —NO2, —C(O)Rn4, —C(O)ORn4, or —C(O)NRq4Rr4;
• each Rn4 is independently H, (C1-C4)alkyl, (C1-C4)haloalkyl, or (C1-C4)heteroalkyl;
• each Rp4 is independently (C1-C8)alkyl, (C1-C4)haloalkyl, or (C1-C4)heteroalkyl;
• each Rq4 and Rr4 is independently H, (C1-C4)alkyl, (C1-C4)haloalkyl, or (C1-C4)heteroalkyl;
• each Z3 is independently a (C1-C4)heteroalkyl;
• each Z4 is independently oxo, (C1-C8)alkyl, (C3-C7)carbocycle, halogen, —CN, —ORn5, NRq5Rr5, —NRn5CORp5, —NRn5CO2Rp5, —C(O)Rn5, —C(O)ORn5, or —C(O)NRq5Rr5, wherein any (C3-C7)carbocycle or (C1-C8)alkyl of Z4 is optionally substituted with 1, 2, 3, 4 or 5 Z4a groups, wherein the Z4a groups are the same or different;
• each Z4a is independently halogen, —CN, or —ORn6;
• each Rn5, Rp5, Rq5, Rr5, and Rn6 is independently H or (C1-C4)alkyl;
• each Z5 is independently halogen, which may be same or different;
• and
• n is 0, 1, 2, or 3;
• or a pharmaceutically acceptable salt thereof.