Polycyclic herg activators

A compound, or salt thereof, of formula (I):

• wherein
• R1 is selected from:
• CO2H or tetrazole and R2 is selected from:
• H, halo, (C1-C4)alkyl or halo-substituted(C1-C4)alkyl, or R1 is H and R2 is CO2H or tetrazole;
• X is selected from:
• H, halo, (C1-C4)alkyl, (C1-C4)alkoxy, NR8R9, halo-substituted(C1-C4)alkyl, phenyl or a 5 to 6 membered heteroaryl containing 1 to 3 heteroatoms each independently selected from O, N, or S, where said phenyl or heteroaryl are optionally substituted with 1 to 2 substituents each independently selected from halo, (C1-C4)alkyl, (C1-C4)alkoxy, halo-substituted(C1-C4)alkyl, hydroxy-substituted(C1-C4)alkyl, (C1-C4)alkylamino-substituted(C1-C4)alkyl, dimethylamino-substituted(C1-C4)alkyl;
• R8 is selected from:
• H, or (C1-C4)alkyl;
• R9 is selected from:
• H, or (C1-C4)alkyl;
• R3 is
• where R3a is selected from:
• H, (C1-C4)alkyl or halo-substituted(C1-C4)alkyl;
• R3b is selected from:
• H, (C1-C4)alkyl or taken together with R3a forms a 3 to 7 membered saturated cycloalkyl or a 3 to 7 membered saturated heterocycle containing 1 to 2 heteroatoms selected from O, S or N;
• R3c is selected from:
• H or CH3;
• R3d is selected from:
• H or CH3;
• R4 is selected from:
• wherein the dotted line indicates the point of attachment;
• R5 is selected from:
• H or CH3;
• R6 is independently selected from:
• halo, nitrile, (C1-C4)alkyl, halo-substituted(C1-C4)alkyl, nitrile-substituted(C1-C4)alkyl, (C1-C4)alkoxy, halo-substituted(C1-C4)alkoxy, nitrile-substituted(C1-C4)alkoxy, (C1-C4)alkylene, N-acetyl, trifluouroacetyl, (C1-C4)alkylthio, halo-substituted thio, halo-substituted (C1-C4)alkylthio, (C3-C6)cycloalkyl, methylamino-substituted(C1-C4)alkyl, dimethylamino-substituted(C1-C4)alkyl, halo-substituted(C1-C4) hydroxyalkyl, a 4 to 6 membered saturated heterocycle containing 1 to 2 heteroatoms selected from O, S or N, or a 5 to 6 membered heteroaryl containing 1 to 3 heteroatoms each independently selected from O, N, or S, where said heterocycle or heteroaryl are optionally substituted with 1 to 2 substituents each independently selected from (C1-C4)alkyl, halo, hydroxyl, amino or (C1-C4)alkoxy;
• R7 is selected from:
• H or halo;
• n is 1, 2 or 3;
• m is 0, 1 or 2;
• or R3c and R4 taken together with the amine to which R3c and R4 are attached forms a fully saturated 4 to 7 membered heterocycle, where 1 to 2 of the ring carbons are each independently optionally replaced with a N or O, and said heterocycle is optionally substituted with 1 to 2 substituents each independently selected from (C1-C4)alkoxy, (C1-C4)alkyl, halo-substituted(C1-C4)alkyl, hydroxy(C1-C4)alkyl, cyclopropyl or oxo or a pharmaceutically acceptable salt thereof.