Novel Compound
AssigneeAstraZeneca AB
InventorsStephen Connolly, Mark Richard Ebden, Iain Alastair Stewart Walters, Thomas Langer, Alan Robert Steven, Craig Robert Stewart, Paula Margaret Tomlin, Andrew John Williams
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Abstract
There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
Claims19
A compound which is (a) a pyrimidine sulfonamide of formula (I), or (b) a pharmaceutically acceptable salt thereof:
A compound which is (a) an azetidine sulfonamide of formula (VIII), or (b) a salt thereof:
A process for preparing a compound of the formula (VI):
- from a compound of the formula (XII):
- wherein Z is selected from 3,4,5-tri-C1-4alkoxyphenyl, 4-phenylphenyl, 4-C1-4alkoxyphenyl, 2-nitrophenyl, 4-nitrophenyl and 3,5-dinitrophenyl.
A compound of the formula (XI′) or a salt thereof:
- wherein R′ is C1-4alkyl.
A compound of the formula (XII′) or a salt thereof:
- wherein R′ is C1-4alkyl.
Dependencies are inferred from the claim text.