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US 2016/0108021 A1Published application
Pyridone derivatives for the treatment of viral infections and further diseases
AssigneeJanssen Sciences Ireland UC
InventorsDavid Craig MC GOWAN, Pierre Jean-Marie Bernard RABOISSON
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Abstract
This invention relates to pyridone derivatives, processes for their preparation, phamaceutical compositions, and their use in therapy.
Claims34
A compound of formula (I)
- or a pharmaceutically acceptable salt, solvate or polymorph thereof, wherein
- R1 is C1-6 alkyl, optionally substituted by one or more substituents independently selected from the group consisting of aryl, halogen, OH, —NH2, —CO2H, CO2C1-3alkyl, —C(O)NHC1-3alkyl, C(O)NHSO2C1-3alkyl, C1-3 alkyl, C3-6 cycloalkyl, SO2C1-3 alkyl, —S(O)C1-3alkyl, —SO2NHC1-3 alkyl, heterocycle and —CN;
- R2, R3, R4, and R5 are each independently selected from the group consisting of hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, C3-6 cycloalkyl, aryl, —CF3 and heterocycle;
- or wherein
- R2 is fused with R3 to form a ring structure,
- R3 is fused with R4 to form a ring structure or
- R4 is fused with R5 to form a ring structure.
4 more elements
(canceled)
A method of preparing a compound of formula 1, said method comprising reacting compounds A, B, C and D as follows:
Dependencies are inferred from the claim text.