Novel Substituted Bicyclic Aromatic Compounds as S-Nitrosoglutathione Reductase Inhibitors

The compound of Formula 1:

• wherein
• R1 is selected from the group consisting of H, F, and Cl;
• R2a and R2b are independently selected from the group consisting of H, F, Cl, Br, Me, OCH3, and cyano;
• R2c is selected from the group consisting of H, F, Cl, Br, Me, and OCH3;
• X is selected from the group consisting of
• A is selected from the group consisting of
• R3 is selected from the group consisting of F, Cl, Br, CH3, CF3, OCH3, cyano, N(CH3)2, and morpholino;
• n is selected from the group consisting of 0, 1, and 2;
• R4 is selected from the group consisting of H, F, Cl, Br, CH3, CF3, OCH3, cyano, N(CH3)2, and morpholino;
• with the proviso that when X is and A is COOH, then at least one of R1, R2a, R2b, R2c, and R4 is not hydrogen, or n must be >0, and R3 when meta to naphthalene, cannot be CH3.