US 2016/0108007 A1Published application

Synthesis of syrbactin proteasome inhibitors

AssigneeThe Regents of the University of California

InventorMichael C. Pirrung

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The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.

Dependent claims

A method to synthesize a compound 1 having the structure of:

comprising reactions (a)-(d):
wherein, R3 is a (C1-C6)alkyl, and Boc is a tert-butyloxycarbonyl protecting group.

Dependencies are inferred from the claim text.

C07K 5/0202
Containing at least one abnormal peptide link: containing the structure -NH-X-X-C-, X being an optionally substituted carbon atom or a heteroatom,…
A61K 38/06
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: tripeptides
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents

From the US filing history. Foreign family members aren’t listed.

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