Universal reader molecule for recognition tunneling
OwnerPeiming ZHANG, Stuart LINDSAY +2inventors
InventorsPeiming ZHANG, Stuart LINDSAY, Sovan BISWAS, Suman SEN
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Abstract
Some embodiments of the present disclosure are directed to a compound 5(6)-mercapto-1H-benzo[d]imidazole-2-carboxamide (“BIA”) which yields enhanced signals for recognition tunneling. Other embodiments are directed toward methods for producing such compounds as well as apparatuses and systems which utilize such compounds for recognition tunneling for molecule identification/sequencing (for example).
Claims9
A compound for trapping and reading an analyte in a tunnel junction, the compound having a structure comprising a five membered aromatic ring fused either with a conductive ring moiety, or a derivative of the conductive ring moiety, thereby enhancing the conductivity of the compound.
A compound of a reader molecule for use in a recognition tunneling apparatus, the reader molecule comprising a fusion of an aromatic ring with a heterocycle, wherein the reader molecule forms complexes with biochemical molecules through non-covalent interactions, the interactions comprising at least one of hydrogen bonding, aromatic interactions, stacking interaction, and hydrophobic interactions, wherein as a result of the formed complexes, tunneling current signals are generated in the recognition tunneling apparatus.
A compound of the formula C8H7N3OS, having a structure given by:
9-22. (canceled)
Dependencies are inferred from the claim text.