Histone demethylase inhibitors
AssigneeQuanticel Pharmaceuticals, Inc.
InventorsAmogh BOLOOR, Young K. CHEN, Michael Brennan WALLACE
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Abstract
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
Claims30
(canceled)
A compound, or pharmaceutically acceptable salt thereof, having the structure of Formula (V):
- wherein,
- X is O or CH2;
- R6 is chosen from optionally substituted heterocyclyl, optionally substituted heterocyclyloxy, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkoxy, optionally substituted C6-C10 aryl-SO2—, optionally substituted heteroaryl-S—, or —N(R1)(R2), wherein R1 is hydrogen or optionally substituted alkyl, and R2 is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl-CO—, optionally substituted heteroaryl-CO—, optionally substituted cycloalkyl-CO—, or optionally substituted alkyl-CO—;
- and
- each R5, R7 and R8 is independently chosen from hydrogen, halogen, —OH, —CN, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, optionally substituted C3-C7 carbocyclyl, optionally substituted C3-C7 carbocyclyloxy, optionally substituted C4-C12 carbocyclylalkyl, optionally substituted C4-C12 carbocyclylalkoxy, optionally substituted C1-C6 alkynyl, optionally substituted C1-C6 alkenyl, optionally substituted C6-C10 aryl, optionally substituted C6-C10 aryloxy, optionally substituted C6-C10 aryl-S—, optionally substituted C7-C14 aralkoxy, optionally substituted heteroaryl, and optionally substituted heteroaryloxy, optionally substituted heterocyclyl, optionally substituted heterocyclyloxy, substituted heterocyclylalkyl, optionally substituted heterocyclylalkoxy, optionally substituted C6-C10 aryl-SO2—, optionally substituted heteroaryl-S—, or —N(R1)(R2), wherein R1 is hydrogen or optionally substituted alkyl, and R2 is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl-CO—, optionally substituted heteroaryl-CO—, optionally substituted cycloalkyl-CO—, or optionally substituted alkyl-CO—;
- with the provision that at least one of R5, R7 and R8 is hydrogen.
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Dependencies are inferred from the claim text.