4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1h-pyrrol-3-yl)benzenesulfonamide as alpha 7 nachr modulator
AssigneeLupin Limited
InventorsNeelima Sinha, Navnath Popat Karche, Ajay Ramchandra Tilekar, Venkata P. Palle, Rajender Kumar Kamboj
Life of this patent
Estimating the term…
Abstract
Disclosed are an alpha 7 nAChR receptor modulator compound, 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yljbenzenesulfonamide, its tautomeric form, its pharmaceutically acceptable salts, pharmaceutical compositions comprising the compound or a salt thereof, and a method of treating various diseases, disorders or conditions, for example, Alzheimer's disease, mild cognitive impairment, senile dementia, vascular dementia, dementia of Parkinson's disease, and attention deficit disorder.
Claims8
4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yl)benzenesulfonamide, a tautomer thereof, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yl)benzenesulfonamide, a tautomer thereof, or a pharmaceutically acceptable and a pharmaceutically acceptable carrier.
A method of preventing or treating a disease or its symptoms, condition, or a disorder mediated partially or completely by nicotinic acetylcholine receptors, said method comprising administering to a subject having or susceptible to said disease or its symptoms or disorder a therapeutically effective amount of 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yl)benzenesulfonamide, a tautomer thereof, or a pharmaceutically acceptable salt thereof.
8-12. (canceled)
Dependencies are inferred from the claim text.