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US 2016/0107160 A1Published application
Microfluidic Size-Exclusion Devices, Systems, and Methods
AssigneeApplied Biosystems, LLC
InventorsSean M. Desmond, Zbigniew T. Bryning, John S. Shigeura, Gary Lim, Adrian Fawcett, Jacob K. Freudenthal, Gary Bordenkircher
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Abstract
Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features are also provided.
Claims18
A microfluidic device comprising:
- a substrate having a first surface, a second surface opposing the first surface, and a thickness;
- a plurality of parallel pathways formed in the substrate, each of the pathways comprising
- an input opening,
- an output opening,
- at least one processing chamber located between the input opening and the output opening, wherein the input opening, the at least one processing chamber, and the output opening are arranged linearly;
- a first fluid communication between the input opening and the at least one processing chamber, and
- a second fluid communication between the at least one processing chamber and the output opening;
- wherein each of the plurality of pathways includes at least one valve that is capable of being opened to form a fluid communication.
5 more elements
A microfluidic device comprising:
- a substrate having a first surface, a second surface opposing the first surface, and a thickness;
- and
- a plurality of parallel pathways formed in the substrate, each of the pathways comprising an input opening, an output opening, at least one processing chamber between the input opening and the output opening, and at least one valve for interrupting or providing fluid communication between the at least one processing chamber and at least one of the input opening and the output opening.
A sample processing assembly comprising:
- a sample processing device comprising:
- a body that comprises a first side attached to a second side;
- a plurality of process arrays formed between the first and second sides, wherein each process array of the plurality of process arrays comprises a loading structure, a main conduit comprising a length, a plurality of process chambers distributed along the main conduit, and a deformable seal located between the loading structure and the plurality of process chambers, wherein the main conduit is in fluid communication with the loading structure and the plurality of process chambers;
- a carrier attached to the sample processing device, the carrier comprising:
- a first surface facing the sample processing device and a second surface facing away from the sample processing device;
- a plurality of main conduit support rails proximate the first surface of the carrier, wherein each main conduit of the plurality of process arrays is aligned with one main conduit support rail of the plurality of main conduit support rails;
- and a plurality of openings formed through the first and second surfaces of the carrier, wherein each opening of the plurality of openings is aligned with one process chamber of the plurality of process chambers.
4 more elements
Dependencies are inferred from the claim text.