Systems And Methods For Providing A Pulse Of A Therapeutic Gas With A Desired Flow Profile To Maximize Therapeutic Effectiveness
AssigneeINO Therapeutics LLC
InventorsThomas Kohlmann, John Klaus
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Abstract
Described are systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness. Systems and methods of the present disclosure can generate and/or provide desired flow profiles with various shapes and/or properties by configuring, modifying, optimizing, and/or factoring in aspects of at least one fixed flow rate assembly of a therapeutic gas delivery system such as, but not limited to, spatial relationships of elements of the fixed flow rate assembly, rate of valve closure and opening, latent flows, transient wave generation and/or propagation, to name a few.
Claims20
A system for providing a pulse of a pharmaceutical gas having a desired flow profile to deliver to a patient, the system comprising:
- a first fixed flow rate assembly including a first fixed flow valve in fluid communication with a first fixed flow orifice, the first fixed flow valve being (1) a fixed flow valve that rapidly opens and rapidly closes, (2) located upstream or downstream of first fixed flow orifice and (3) at a volumetric offset from the first fixed flow orifice;
- and
- a flow delivery control that rapidly opens and rapidly closes the first fixed flow orifice located at least one of upstream or downstream of, and at the volumetric offset from, the first fixed flow valve to provide a pulse of a pharmaceutical gas having a desired flow profile to a patient.
A method of providing a pulse of a pharmaceutical gas with a desired flow profile to deliver to a patient, the method comprising:
- rapidly opening a first fixed flow valve that is located upstream from a first fixed flow orifice to commence delivery of a first dose of a pharmaceutical gas in a pulse having a desired flow profile to a patient that abruptly increases flow to a desired initial flow rate over negligible time;
- rapidly closing the first fixed flow valve to end flow, through the first fixed flow valve, of the pharmaceutical gas;
- and
- providing a waning flow of the pharmaceutical gas after rapidly closing the first fixed flow valve to complete delivery, to the patient, of the pulse of the pharmaceutical gas with the desired flow profile, wherein the waning flow is generated in response to arranging the first fixed flow valve at a volumetric offset from the first fixed flow orifice such that the waning flow is at least one of reduced by lessening the volumetric offset or increased by increasing the volumetric offset.
A method of providing a pulse of a pharmaceutical gas with a desired flow profile to deliver to a patient, the method comprising:
- rapidly opening a first fixed flow valve that is located downstream from a first fixed flow orifice to commence delivery of a first dose of a pharmaceutical gas in a pulse having a desired flow profile to a patient that abruptly increases flow to a desired initial flow rate including an initial flow spike over negligible time, wherein the initial flow spike is generated in response to arranging the first fixed flow valve at a volumetric offset from the first fixed flow orifice such that the initial flow spike is at least one of reduced by lessening the volumetric offset or increased by increasing the volumetric offset;
- and
- rapidly closing the first fixed flow valve to end flow, through the first fixed flow valve, of the pharmaceutical gas to complete delivery, to the patient, of the pulse of the pharmaceutical gas with the desired flow profile.
Dependencies are inferred from the claim text.