Targeted apheresis for the treatment of rheumatoid arthritis and immune disorders
OwnerHenry J. Smith, James R. Smithinventors
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Abstract
This invention uses “Targeted Apheresis” to treat patients with Rheumatoid Arthritis and other autoimmune and inflammatory disorders. “Targeted Apheresis” is a process whereby only the pathogenic and pro-inflammatory elements associated with the disease symptoms are simultaneously and selectively removed from the blood by passing the blood through an extracorporeal affinity device containing selective binding agents. Removal of these pathogenic and pro-inflammatory elements will ameliorate the symptoms of autoimmune disease and may prolong the period of disease remission.
Claims13
A means of selectively removing pathological, pro-inflammatory and disease inciting factors from the blood of patients with rheumatoid arthritis and other autoimmune diseases using targeted apheresis.
A method of targeted apheresis for treating patients with systemic lupus erythematosus (SLE) using an extracorporeal affinity device containing two or more immobilized binding agents selected from the list of:
- immobilized nuclear extract agarose beads;
- “altered IgG” binding agent agarose beads;
- TNF-alpha binding agent agarose beads, and IL-1 binding agent agarose beads.
A method of targeted apheresis for treating patients with myasthenia gravis (MG) using an extracorporeal affinity device containing two or more immobilized binding agents selected from the list of:
- immobilized anti-acetylcholine antibody binding agent agarose beads;
- immobilized TNF-alpha binding agent agarose beads;
- and immobilized IL-1 binding agent agarose beads.
A method of targeted apheresis for treating osteoarthritis patients using an extracorporeal affinity device containing two or more immobilized binding agents selected from the list of:
- “altered IgG” agarose beads, “altered IgG” binding agent agarose beads;
- TNF-alpha binding agent agarose beads, and IL-1 binding agent agarose beads.
Dependencies are inferred from the claim text.