Collagen Material and Composites for Ocular Application
AssigneeThe Johns Hopkins University
InventorsXiomara Calderon-Colon, Annie M. Dunn, Marcia W. Patchan, Morgana M. Trexler
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Abstract
A method for preparing a collagen membrane includes applying an influence of an electric field to a collagen solution positioned between capacitor plates; adding a buffer solution to the acidic collagen solution to form a collagen gel; assembling a plurality of collagen gel layers; and performing a dehydrothermal cross-link on the plurality of collagen gel layers to form a cross-linked collagen membrane.
Claims20
A method for preparing a collagen membrane, the method comprising:
- applying an influence of an electric field to an acidic collagen solution positioned between two capacitor plates;
- adding a buffer solution to the acidic collagen solution to form a collagen gel;
- assembling a plurality of collagen gel layers;
- and
- performing a dehydrothermal cross-link on the plurality of collagen gel layers to form a cross-linked collagen membrane.
A method for preparing a collagen composite, the method comprising:
- forming a collagen solution;
- coaxially electrospinning the collagen solution and at least one polymer to form collagen composite nanofibers;
- and
- collecting the collagen composite nanofibers.
A collagen composite, comprising:
- a collagen shell;
- and
- a polymer core, the polymer core comprising at least one of a therapeutic polymeric composition, a sensory polymeric composition, or any combination thereof,
- wherein the collagen shell and the polymer core are coaxially electrospun together to form the collagen composite.
Dependencies are inferred from the claim text.