Composite scaffold for tissue repair
AssigneesOspedale San Raffaele S.R.L., Università Al Salento
InventorsGiuseppe PERETTI, Gianfranco FRASCHINI, Alessandro SANNINO, Francesca GERVASO, Francesco SCALERA, Alessia Di GIANCAMILLO, Cinzia DOMENEGHINI, Daniela Rosa DEPONTI
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Abstract
A synthetic composite material for tissue repair is disclosed which includes a first layer having an organic material and having side walls and external surface; and a second porous layer comprising an inorganic material and having side walls; wherein the first layer is in direct contact with the second layer and wherein the side walls of the first layer and the side walls of the second layer are coated with a third layer of the organic material.
Claims31
A synthetic composite material for tissue repair comprising:
- a first layer comprising an organic material and having side walls and external surface;
- a second porous layer comprising an inorganic material and having side walls;
- wherein said first layer is in direct contact with said second layer and wherein the side walls of the first layer and the side walls of the second layer are coated with a third layer comprising the organic material.
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A process for the preparation of a synthetic composite material comprising a first layer comprising an organic material and a second layer comprising an inorganic material comprising the steps of:
- a) pouring in a first mold a slurry composition comprising a liquid carrier and an organic material;
- b) inserting in the mold a material comprising an inorganic material;
- c) performing a freeze-dry cycle;
- d) inducing dehydrothermal crosslinking to obtain an intermediate material;
- e) removing the intermediate material from the first mold;
- f) introducing at least one intermediate material in a second mold having an internal area larger than the first mold;
- g) pouring the slurry composition comprising the liquid carrier and the organic material until the mold is filled;
- h) performing a freeze-dry cycle;
- i) inducing dehydrothermal crosslinking and
- j) optionally sterilizing the material.
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Dependencies are inferred from the claim text.