Novel peptide hydrogels generating chemical exchange saturation transfer mri contrast and uses thereof
AssigneesThe Johns Hopkins University, Kennedy Krieger Institute, Inc., National Institute of Health
InventorsMichael T. McMahon, Kannie Wai-Yan Chan, Michael Christopher Giano, Nikita Oskolkov, Joel Patrick Schneider, Xiaolei Song
Life of this patent
Estimating the term…
Abstract
The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions.
Claims20
An agent for use in conjunction with magnetic resonance (MR) imaging comprising:
- a biocompatible chemical exchange saturation transfer (CEST) agent;
- wherein said biocompatible CEST agent takes the form of a peptide-based hydrogel;
- and
- wherein said biocompatible CEST agent is configured to create contrast in an MR image detectable using a saturation transfer CEST method of MR imaging.
A method for magnetic resonance (MR) imaging of a subject comprising:
- providing a biocompatible chemical exchange saturation transfer agent (CEST) contrast agent formed from a peptide-based hydrogel;
- delivering the biocompatible CEST contrast agent to the subject;
- and
- using a CEST method of MR imaging to obtain an MR image of the subject.
Dependencies are inferred from the claim text.