Re-Directed Immunotherapy

An agent for retargeting T cells to solid tumor cells, the agent comprising:

• (i) a targeting moiety that is capable of targeting to the solid tumor cells, wherein the targeting moiety is an antibody or antigen binding region thereof;
• and
• (ii) a viral derived T cell antigen,
• wherein the T cell antigen can be released from the targeting moiety by selective cleavage of a cleavage site in the agent that is cleavable by a tumor associated protease selectively in the vicinity of the solid tumor cells;
• wherein selective cleavage of the cleavage site enables release of the T cell antigen in the vicinity of, and outside of, the solid tumor cell, and wherein the solid tumor is not a lymphoma.