Methods And Compositions For Templated Assembly Of Nucleic Acid Specific Heterocompounds

A targeted templated assembly reactant comprising:

• a) at least one nucleic acid recognition moiety;
• b) at least one bio-orthogonal moiety;
• and
• c) at least one effector partial moiety.

A method of synthesizing a templated assembly reactant, said method comprising:

• generating at least one nucleic acid recognition moiety that is capable of binding a target nucleic acid sequence;
• generating at least one selectively-reactive moiety that is capable of binding a corresponding selectively-reactive moiety;
• and
• generating at least one effector partial moiety that is capable of binding a corresponding effector partial moiety to produce an active effector structure.

A method of synthesizing an active effector structure, said method comprising:

• generating at least two templated assembly reactants, wherein said reactants comprise:
• at least one nucleic acid recognition moiety that binds a target nucleic acid sequence within a target sample,
• at least one selectively-reactive moiety, and
• at least one effector partial moiety;
• contacting the targeted templated assembly reactants to a target nucleic acid sequence;
• and
• producing an active effector structure.

A method of delivering at least two targeted templated assembly reactants to a pathogenic cell, said method comprising:

• administering a therapeutically effective amount of the targeted templated assembly reactants to the pathogenic cell, wherein said reactants are each comprised of:
• at least one nucleic acid recognition moiety that binds a target nucleic acid sequence within the target pathogenic cell,
• at least one selectively-reactive moiety, and
• at least one effector partial moiety;
• and
• producing at least one active effector structure in the pathogenic cell.