Curcumin conjugates for treating and preventing cancers
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsWilliam Hansel, Sita Aggarwal, Robert P. Hammer
Life of this patent
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Abstract
Conjugating LHRH to curcumin (LHRH-Curcumin) substantially enhances the bioavailability of curcumin, targets it to cells expressing LHRH receptors, facilitates intravenous administration, and increases the anti-cancer efficacy of curcumin. The conjugate may be used against cancer cells that express the LHRH receptor: pancreas, prostate, breast, testicular, uterine, ovarian, melanoma. LH-Curcumin conjugates may be used against cancer cells that express the LH receptor: prostate, breast, ovary, testis, uterus, pancreas, and melanoma.
Claims25
A compound comprising:
- (a) a hormone domain comprising luteinizing hormone-releasing hormone, or luteinizing hormone, or chorionic gonadotropin, or an analog of one of these hormones;
- covalently linked to:
- (b) a curcumin domain comprising curcumin or a curcumin analog.
Dependencies are inferred from the claim text.