Targeted therapeutic nanoparticles
AssigneenanoDERM Sciences, Inc.
InventorsRoy R. Yeoman, Richard A. Winchurch
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Abstract
Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.
Claims20
A nanoparticle targeting molecule, comprising:
- a polymeric network comprising a plurality of first block copolymeric segments derived from epoxide monomers and a plurality of second polymeric segments derived from polysaccharides;
- and
- targeting agents chemically attached to the polymeric network.
A cross-linked polymeric nanogel, comprising:
- a plurality of first polymeric segments derived from poloxamers;
- a plurality of second polymeric segments derived from a polysaccharide, wherein the first polymeric segments and the second polymeric segments are bonded together to form a polymeric network;
- a targeting agent covalently bonded to the second polymeric segments derived from a polysaccharide;
- water encapsulated within the polymeric network;
- and
- medicaments encapsulated within the polymeric network.
A method of forming a targeting nanoparticle, comprising:
- reacting a polymyxin with a functional group chemically attached to a polysaccharide;
- and
- copolymerizing polysaccharide monomers and poloxamer monomers to form a nanogel.
Dependencies are inferred from the claim text.