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US 2016/0106850 A1Published application
Methods and Compositions For Wound Treatment
AssigneeLeidos, Inc.
InventorsJohn Dresios, Richard Griffey
Life of this patent
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Abstract
The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
Claims12
A composition for treatment of a wound in a subject comprising:
- a carrier,
- a hemostatic agent and
- a wound targeting moiety comprising an antibody specific for actin, wherein the carrier is conjugated to the antibody and, further wherein the wound targeting moiety facilitates local delivery of the hemostatic agent to wounded tissue by binding to an actin protein exposed upon wounding of the subject.
A composition for treatment of a wound in a subject comprising:
- a carrier,
- a hemostatic agent, and
- a wound targeting moiety comprising an antibody specific to a cryptic tripeptide arginine-glycine-aspartic acid (RGD) epitope, wherein the carrier is conjugated to the antibody, and wherein the antibody facilitates local delivery of the hemostatic agent to wound tissue by binding to an exposed cryptic tripeptide arginine-glycine-aspartic acid (RGD) epitope exposed upon wounding of the subject.
A composition for treatment of a wound in a subject comprising:
- a carrier,
- an anticoagulant and
- a wound targeting moiety comprising an antibody specific for actin, wherein the carrier is conjugated to the antibody and, further wherein the wound targeting moiety facilitates local delivery of the anticoagulant agent to wounded tissue by binding to an actin protein exposed upon wounding of the subject.
Dependencies are inferred from the claim text.