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US 2016/0106847 A1Published application
Low-burst polymers and methods to produce polymer
AssigneeTolmar Therapeutics, Inc.
InventorsEric Dadey, John Middleton, Richard L. Norton
Life of this patent
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Abstract
A PLG copolymer material, termed a PLG(p) copolymer material, adapted for use in a controlled release formulation for a bioactive material is provided, wherein the formulation exhibits a reduced “initial burst” effect when introduced into the tissue of a patient in need thereof. A method of preparation of the PLG copolymer material is also provided, as are methods of use.
Claims21
1-40. (canceled)
A controlled release formulation comprising a flowable delivery system comprising:
- an organic solvent, a bioactive agent and a biocompatible, biodegradable, non-hydrolyzed PLG low-burst copolymer material having a weight average molecular weight of about 15 kilodaltons to about 50 kilodaltons and a polydispersity index of about 1.4 to about 1.8 and which low-burst copolymer material is substantially free of a copolymer fraction characterized by a weight average molecular weight of about 4 kDa to about 10 kDa and a polydispersity index of about 1.4 to 2.5.
Dependencies are inferred from the claim text.