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US 2016/0106844 A1Published application
Alternative formulations for tnfr: fc fusion polypeptides
OwnerCarlos Bañado, Tamal Raha +1inventors
InventorsCarlos Bañado, Tamal Raha, Cédric Bes
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Abstract
The present invention relates to aqueous stable pharmaceutical compositions suitable for storage of polypeptides that contain TNFR:Fc.
Claims17
An aqueous composition comprising:
- an isolated polypeptide that is an extracellular ligand-binding portion of a human p75 tumor necrosis factor receptor fused to the Fc region of a human IgG1;
- salt present at a concentration of between 80 and 130 mM;
- an aqueous buffer, wherein the aqueous buffer is sodium and/or potassium phosphate buffer and wherein the aqueous buffer is present at a concentration of between 20 and 30 mM;
- and
- an excipient which is sucrose, wherein the concentration of sucrose is between 34 and 80 mg/mL,
- characterized in that neither arginine nor cysteine are present in the composition.
3 more elements
An aqueous composition comprising:
- an isolated polypeptide that is an extracellular ligand-binding portion of a human p75 tumor necrosis factor receptor fused to the Fc region of a human IgG1;
- salt present at a concentration of from 80 to 130 mM, wherein the salt is not present at a concentration of 100 mM;
- an aqueous buffer, wherein the aqueous buffer is succinate buffer;
- and
- an excipient selected from the group of consisting of trehalose, sucrose, and a combination thereof, wherein no free amino acids are present in the composition.
2 more elements
Dependencies are inferred from the claim text.