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US 2016/0106824 A1Published application
Yeast-brachyury immunotherapeutic compositions
AssigneesGlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
InventorsClaudia Palena, Zhimin Guo, David Apelian, Jeffrey Schlom
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Abstract
Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.
Claims22
-105. (canceled)
A method to reduce tumor burden in an individual, increase survival of an individual, and/or inhibit tumor growth in an individual, comprising administering to the individual an immunotherapeutic composition comprising.
- a) a whole, inactivated yeast;
- and
- b) a Brachyury fusion protein comprising the amino acid sequence of positions 2-435 of SEQ ID NO:6 or the amino acid sequence of positions 2-435 of SEQ ID NO:18;
- wherein the Brachyury fusion protein is expressed by the yeast;
- and wherein the composition elicits a Brachyury-specific T cell response.
2 more elements
Dependencies are inferred from the claim text.