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US 2016/0106822 A1Published application
Pcsk9 peptide combination vaccine and method of use
AssigneeAffiris AG
InventorsSylvia BRUNNER, Gergana Galabova, Bettina Wanko, Markus Windwarder, Gabriele Winsauer, Guenther Staffler, Claudia Juno
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Abstract
The present invention relates to a immunogen comprising at least two fragments of Proprotein convertase subtilisin/kexin type 9 (PCSK9), wherein at least two fragments comprise at least 8 consecutive amino acid residues of amino acid residues 150 to 170 and/or 205 to 225 of PCSK9 (SEQ ID NO:9).
Claims20
An immunogen comprising at least two separate fragments of Proprotein convertase subtilisin/kexin type 9 (PCSK9),
- wherein a first fragment of said at least two fragments comprises at least 8 consecutive amino acid residues of amino acid residues 150 to 170, and
- wherein a second fragment of said at least two fragments comprises at least 8 consecutive amino acid residues of amino acid residues 205 to 225 of PCSK9 (SEQ ID NO:9).
The immunogen according to 1, further comprising at least aluminum hydroxide or another adjuvant.
Dependencies are inferred from the claim text.