Method of Treatment
AssigneeHexima Limited
InventorsNicole Louise Van Der Weerden, Marilyn Anne Anderson
Life of this patent
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Abstract
The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.
Claims21
A method for treating infection by a fungal pathogen in a nail or keratin comprising material or follicle for the keratin comprising material on a subject, said method comprising contacting the envelope or protrusion or keratin comprising material with an effective amount of plant defensin having the consensus amino acid sequence set forth in SEQ ID NO:24 or a functional natural or synthetic derivative or variant thereof or a defensin having at least 80% similarity to SEQ ID NO:24 after optimal alignment or wherein SEQ ID NO:24 has an optional N-terminal alanine residue for a time and under conditions sufficient to ameliorate symptoms of the infection.
(canceled)
A topical formulation or cell or plant extract comprising plant defensin having the consensus amino acid sequence set forth in SEQ ID NO:24 or a functional natural or synthetic derivative or variant thereof or a defensin having at least 80% similarity to SEQ ID NO:24 after optimal alignment or wherein SEQ ID NO:24 has an optional N-terminal alanine residue and one or more pharmaceutically acceptable carriers, diluents and/or excipients for use in treating fungal infection.
Dependencies are inferred from the claim text.