Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress
AssigneesAlba Therapeutics Corporation, University of Maryland, Baltimore
InventorsBlake Paterson, Peter Ward, Alessio Fasano
Life of this patent
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Abstract
The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
Claims39
A method of treating an excessive or undesirable permeability of lung tissue containing tight junctions comprising:
- administering to a subject in need thereof a composition comprising a tight junction antagonist.
A method according to claim 7, wherein the composition and the additional therapeutic agent are administered simultaneously.
A method of treating acute respiratory distress syndrome, comprising:
- administering to a subject in need thereof a composition comprising a tight junction antagonist.
A method of treating acute lung injury, comprising:
- administering to a subject in need thereof a composition comprising a tight junction antagonist.
A composition formulated for pulmonary delivery comprising a tight junction antagonist.
Dependencies are inferred from the claim text.