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US 2016/0106802 A1Published application
Methods of diagnosing and treating asthma
AssigneeAlba Therapeutics Corporation
InventorBlake Paterson
Life of this patent
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Abstract
The present invention provides materials and methods to diagnose asthma. In some embodiments, the present invention provides a method of diagnosing asthma by measuring the zonulin level of a subject. The present invention also provides methods and compositions for treating asthma that comprise one or more zonulin antagonist.
Claims37
A method of diagnosing asthma in a subject, comprising:
- obtaining a sample from the subject;
- and
- determining zonulin in the sample, wherein the presence of zonulin is predictive of asthma.
A kit for diagnosing asthma, comprising:
- means for detecting zonulin;
- and
- means for detecting at least one cytokine.
A method for treating asthma in a subject in need thereof, comprising:
- contacting the subject with a composition comprising a tight junction antagonist.
A method of monitoring the treatment of asthma in a subject, comprising:
- obtaining a first sample from the subject;
- and
- determining zonulin level in the first sample;
- obtaining a second sample;
- determining zonulin level in the second sample,
- wherein a difference in zonulin level between the first sample and the second sample is indicative of a change in severity of asthma in the subject.
3 more elements
Dependencies are inferred from the claim text.