Methods for the prevention or treatment of heart failure
AssigneesUniversity of Washington, Cornell University
InventorsHazel H. Szeto, Peter S. Rabinovitch, Dao-Fu Dai
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Abstract
The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.
Claims13
A method of treating heart failure or hypertensive cardiomyopathy in a mammalian subject, comprising administering to the mammalian subject in need thereof a therapeutically effective amount of the peptide D-Arg-2′6′-Dmt-Lys-Phe-NH2 or Phe-D-Arg-Phe-Lys-NH2.
A method for increasing myocardial contractility and cardiac output in a subject suffering from heart failure or hypertensive cardiomyopathy comprising administering to the subject a therapeutically effective amount of the peptide D-Arg-2′6′-Dmt-Lys-Phe-NH2 or Phe-D-Arg-Phe-Lys-NH2.
Dependencies are inferred from the claim text.