Carbohydrate Compounds for Nutritional and Therapeutic Use
AssigneeSiamab Therapeutics, Inc.
InventorsMai Zhang, Darius Ghaderi, Jeffrey Behrens, Julie DeSander, Ajit Varki
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Abstract
Embodiments of the present invention provide compositions and methods for the modulation of sialic acid levels. In some embodiments, compositions disclosed herein comprise nutraceuticals as functional agents.
Claims11
1-17. (canceled)
A method of reducing inflammation comprising providing to a patient in need thereof a nutraceutical composition, said nutraceutical composition comprising glycomacropeptide (GMP) and wherein levels of each of interferon γ, interleukin (IL)-5, IL-6, keratinocyte chemoattractant, monocyte chemotactic protein 1, and tumor necrosis factor α are reduced.
(canceled)
(canceled)
A method of evaluating the ability of a nutraceutical composition to modulate inflammation in vivo comprising:
- a. administering said nutraceutical composition to a mammal, said nutraceutical composition comprising GMP,
- b. obtaining a first sample from the mammal,
- c. obtaining a second sample from the mammal, wherein said second sample is obtained from about 1 week to about 12 weeks after obtaining said first sample,
- d. determining the level of interferon γ, IL-5, IL-6, keratinocyte chemoattractant, monocyte chemotactic protein 1, and tumor necrosis factor α in said first sample and in said second sample, and
- e. comparing the level of interferon γ, IL-5, IL-6, keratinocyte chemoattractant, monocyte chemotactic protein 1, and tumor necrosis factor α determined in said second sample to the level of interferon γ, IL-5, IL-6, keratinocyte chemoattractant, monocyte chemotactic protein 1, and tumor necrosis factor α determined in said first sample.
A method of incorporating sialic acid into one or more tissues comprising administering to a patient in need thereof a nutraceutical composition, said nutraceutical composition comprising GMP.
24-33. (canceled)
Dependencies are inferred from the claim text.