Inhibition of Neurodegenerative Disease by Grape Seed Extract, Green Tea Extract and Probiotic Bacteria
OwnerGil NOFAR, Uri COGANinventors
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Abstract
A composition is provided comprising extracts of at least grape seeds (GSE) and green tea. The extracts are preferably polyphenolic and preferably comprise probiotic bacteria. The use of extracts from green tea and grape seeds for the manufacture of a medicament against a neurodegenerative disease is also disclosed.
Claims19
A composition comprising extracts of grape seeds (GSE), green tea, and probiotic bacteria.
A composition comprising polyphenol extracts from at least two plants, and probiotic bacteria.
Capsules comprising:
- EGCG polyphenols;
- probiotic bacteria selected from L. plantarum, bifidobacteria, and mixtures thereof, and polyphenol extract from GSE.
Treatment of a neurodegenerative disease consisting of administering to a patient a composition comprising probiotic bacteria and polyphenolic extracts from green tea and grape seeds.
Improving cognition in a patient consisting of administering to the patient a composition comprising probiotic bacteria, and extracts from green tea and grape seeds.
Manufacture of grape seed extract comprising:
- contacting a member selected from the group consisting of whole grapes, grape seeds, grape pomace, and mixtures thereof with water at an elevated temperature to obtain a crude grape-water extract;
- treating the crude grape-water extract with a tannase enzyme at an elevated temperature to obtain a polyphenol grape extract;
- acidifying the polyphenol grape extract to a pH of about 1.5 to 2.5 to obtain an acidified polyphenol extract;
- cooling the acidified polyphenol extract, and
- filtering the cooled acidified polyphenol extract to obtain a filtered polyphenol extract, wherein the polyphenols consist of low molecular weight polyphenols, and wherein the Grape seeds are unfermented.
Dependencies are inferred from the claim text.