Pharmaceutical compositions

A solid oral pharmaceutical composition that comprises:

• a first matrix formulated for controlled release comprising a triptan;
• and
• a second matrix formulated for immediate release comprising an antiemetic.

A solid oral pharmaceutical composition for treating chronic pain, and reducing or preventing opioid-induced nausea or vomiting in a subject in need thereof, comprising:

• a matrix formulated for immediate-release comprising an antiemetic;
• and
• a matrix formulated for controlled-release comprising an opioid analgesic and a non-opioid analgesic, wherein about 90% of the antiemetic is released in about 1 minute to about 20 minutes following contact of the solid composition with a dissolution fluid as measured by a USP Apparatus 2 (Paddle Apparatus), wherein about 30% to about 60% of the opioid analgesic is released in about 5 to 10 minutes following contact of the solid oral pharmaceutical composition with a dissolution fluid as measured by a USP Apparatus 2 (Paddle Apparatus), wherein about 100% of the opioid analgesic is released in about 60 minutes following contact of the solid oral pharmaceutical composition with a dissolution fluid as measured by a USP Apparatus 2 (Paddle Apparatus), wherein the solid oral pharmaceutical composition provides an effective amount of the opioid analgesic and the non-opioid analgesic to treat chronic pain, and wherein the solid oral pharmaceutical composition provides an effective amount of the antiemetic to reduce or prevent nausea associated with the opioid analgesic or vomiting associated with the opioid analgesic.