Small molecular inhibitors of rad51 recombinase and methods thereof

A method of treating or preventing cancer in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a pharmaceutically effective amount of a compound selected from the group consisting of Formula (1), Formula (2), Formula (3), a salt thereof, and combinations thereof:

• wherein in (1):
• R1 and R2 are independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 substituted alkyl, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, —(C1-C6)alkylene-phenyl, —(C1-C6)alkylene-substituted phenyl, —(C1-C6)alkylene-heteroaryl, and —(C1-C6)alkylene-substituted heteroaryl;
• R3 is H, C1-C6 alkyl, O(C1-C6 alkyl), F, Cl, Br or I;
• or a salt thereof,
• the method further comprising administering to the subject a treatment selected from the group consisting of (i) radiation therapy, and (ii) a pharmaceutically effective amount of a chemotherapeutic agent;
• whereby treating or preventing the cancer in the subject.