Methods to inhibit infection during wound healing with topical compositions including amino acids

A method that inhibits infection during wound healing by topical application of a single composition that contacts a wound for a period of time to initiate wound healing, said single composition comprising:

• a mixture of powdered amino acids in the following proportional number of moles, plus or minus 5 percent:
• histidine monohydrochloride monohydrate, 9.743 mmol;
• isoleucine, 54.594 mmol;
• leucine, 109.264 mmol;
• lysine acetate, 21.402 mmol;
• methionine, 21.229 mmol;
• phenylalanine, 27.034 mmol;
• threonine, 29.062 mmol;
• tryptophan, 5.424 mmol;
• valine, 61.095 mmol;
• alanine, 50.321 mmol;
• arginine acetate, 28.227 mmol;
• aspartic acid, 54.582 mmol;
• glutamine, 76.100 mmol;
• glycine, 46.232 mmol;
• proline, 36.684 mmol;
• serine, 24.130 mmol;
• and tyrosine, 4.012 mmol;
• said mixture of powdered amino acids being mixed in an exudate in and around a wound site.

A method that inhibits infection during wound healing by topical application of a single composition that contacts a wound for a period of time to initiate wound healing, said single composition comprising one of the following amino acids:

• histidine;
• isoleucine;
• leucine;
• lysine;
• methionine;
• phenylalanine;
• threonine;
• valine;
• alanine;
• arginine;
• glutamine;
• glycine;
• proline;
• and serine;
• each of said one of the following amino acids providing an osmolarity of at least 120 mmol/liter, when mixed in one of:
• water, and an aqueous exudate in and around a wound site;
• said osmolarity of said at least 120 mmol/liter being determined by a maximum aqueous solubility of each of said one of the following amino acids.

A method that inhibits infection during wound healing by topical application of a single composition that contacts a wound for a period of time to initiate wound healing, said single composition comprising one of the following amino acids:

• lysine;
• threonine;
• valine;
• alanine;
• arginine;
• proline;
• and serine;
• each of said one of the following amino acids providing a hyperosmotic osmolarity of at least 650 mmol/liter, when mixed in one of:
• water, and an aqueous exudate in and around a wound site;
• said hyperosmotic osmolarity of said at least 650 mmol/liter being determined by a maximum aqueous solubility of each of said one of the following amino acids.

A method that inhibits infection during wound healing by topical application of a single composition that contacts a wound for a period of time to initiate wound healing, said single composition comprising one of the following amino acids:

• lysine;
• alanine;
• arginine;
• proline;
• and serine;
• each of said one of the following amino acids providing a hyperosmotic osmolarity of at least 1000 mmol/liter, when mixed in one of:
• water, and an aqueous exudate in and around a wound site;
• said hyperosmotic osmolarity of said at least 1000 mmol/liter being determined by a maximum aqueous solubility of each of said one of the following amino acids.

A method that inhibits infection during wound healing by topical application of a single composition that contacts a wound for a period of time to initiate wound healing, said single composition comprising:

• at least two of the following amino acids:
• histidine;
• isoleucine;
• leucine;
• lysine;
• methionine;
• phenylalanine;
• threonine;
• tryptophan;
• valine;
• alanine;
• aspartic acid;
• arginine;
• aspartic acid;
• glutamine;
• glycine;
• proline;
• serine;
• and tyrosine, excepting the pairs of aspartic acid-tryptophan, aspartic acid-tyrosine, and tryptophan-tyrosine, and the triplet of aspartic acid-tryptophan-tyrosine;
• at least two of said amino acids, excepting the pairs of aspartic acid-tryptophan, aspartic acid-tyrosine, and tryptophan-tyrosine, and the triplet of aspartic acid-tryptophan-tyrosine, provide an osmolarity of at least 120 mmol/liter, when mixed in one of:
• water, and an aqueous exudate in and around a wound site;
• said osmolarity of said at least 120 mmol/liter being determined by a maximum aqueous solubility of each constituent of said at least two of said amino acids.