Nitric oxide scavengers
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsSujatha Karoor, Ton That Hai, Cong Jiang, Paul Sanders, Cliff Holmes
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Abstract
Therapeutic compositions capable of removing excess nitric oxide are provided. The therapeutic compositions include nitronyl nitroxide monoradicals, B12 derivatives, flavonoid derivatives, the like and combinations thereof. The therapeutic compositions can be utilized in a number of suitable applications, such as to prevent or treat intradialytic hypotension during dialysis.
Claims11
A composition capable of removing excess nitric oxide comprising a pharmaceutically active agent selected from the group consisting of a nitronyl nitroxide monoradical, a flavonoid derivative, and combinations thereof.
A dialysis solution comprising:
- a composition including a pharmaceutically active agent selected from the group consisting of a nitronyl nitroxide monoradical, a B12 derivative, a flavonoid derivative, and combinations thereof, wherein the composition is capable of removing excess nitric oxide.
A pharmaceutical agent in solution form, the pharmaceutical agent comprising a compound selected from the group consisting of a nitronyl nitroxide monoradical, a flavonoid derivative and combinations thereof wherein the pharmaceutical agent is capable of removing an excess amount of nitric oxide at a cellular level without inhibiting nitric oxide synthesis.
Dependencies are inferred from the claim text.