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US 2016/0106706 A1Published application
Method of delivering an anti-cancer agent to a cell
AssigneeAgency for Science, Technology and Research
InventorsJackie Y. Ying, Joo Eun Chung, Motoichi Kurisawa
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Abstract
There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.
Claims20
-32. (canceled)
A micellar nanocomplex comprising:
- an anti-cancer agent that is a protein;
- and
- a conjugate of:
- (i) aldehyde-terminated polyethylene glycol;
- and
- (ii) a flavonoid that is either monomeric (−)-epigallocatechin gallate or oligomeric (−)-epigallocatechin gallate,
- the micellar nanocomplex having the polyethylene glycol conjugated at the C6 and/or the C8 position of the A ring of the flavonoid by attachment of the polyethylene glycol via reaction of the free aldehyde group with the C6 and/or C8 position of the A ring of the flavonoid, and exhibiting an anti-cancer effect on a cell as a result of a synergistic effect between the anti-cancer effect of the anti-cancer agent and the anti-cancer effect of the flavonoid,
- wherein when the flavonoid is monomeric (−)-epigallocatechin gallate, the micellar nanocomplex further comprises non-conjugated oligomeric (−)-epigallocatechin gallate in an inner core of the micellar nanocomplex,
- wherein the anti-cancer agent is complexed with either the conjugated or non-conjugated oligomeric (−)-epigallocatechin gallate, whichever is present.
6 more elements
Dependencies are inferred from the claim text.