Pharmaceutical compositions comprising droxidopa
AssigneeLundbeck NA Ltd.
InventorsMichael J. Roberts, Simon Pedder
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Abstract
The present invention provides combinations of droxidopa and one or more further pharmaceutically active compounds, said further compounds preferentially being selected from the group of COMT inhibiting compounds, cholinesterase inhibiting compounds, and monoamine oxidase inhibiting compounds. The invention further provides methods of treating conditions, such as orthostatic hypotension, comprising administering the combinations.
Claims39
A pharmaceutical composition comprising droxidopa in combination with one or more additional compounds selected from the group consisting of catechol-O-methyltransferase inhibiting compounds, cholinesterase inhibiting compounds, monoamine oxidase inhibiting compounds, and combinations thereof.
A method for increasing the half-life of droxidopa in a mammal comprising administering the droxidopa to the mammal in combination with one or more additional compounds selected from the group consisting of catechol-O-methyltransferase inhibiting compounds, cholinesterase inhibiting compounds, monoamine oxidase inhibiting compounds, and combinations thereof.
A method for increasing the volume of distribution of droxidopa in a mammal comprising administering the droxidopa to the mammal in combination with one or more additional compounds selected from the group consisting of catechol-O-methyltransferase inhibiting compounds, cholinesterase inhibiting compounds, monoamine oxidase inhibiting compounds, and combinations thereof.
A method of treating orthostatic hypotension comprising administering to a subject in need of treatment for orthostatic hypotension a therapeutically effective amount of droxidopa and a therapeutically effective amount of one or more additional compounds selected from the group consisting of catechol-O-methyltransferase inhibiting compounds, cholinesterase inhibiting compounds, monoamine oxidase inhibiting compounds, and combinations thereof.
Dependencies are inferred from the claim text.