Use of x-ray contrast media and related compositions for the treatment and prevention of a filovirus infection

A method of treating, preventing or slowing a filovirus infection in a mammal, comprising providing or administering to a mammal in need thereof a composition comprising a compound of Formula I or Formula II or a pharmaceutically acceptable salt or ester thereof in an amount sufficient to treat, prevent or slow said filovirus infection, wherein Formula I has the following structure:

• and Formula II has the following structure:
• wherein each R1 is independently selected from the group consisting of hydrogen, halogen, nitro, amino, hydroxyl, cyano, optionally substituted C1-C24 alkyl, optionally substituted C2-C24 alkenyl, optionally substituted C2-C24 alkynyl, acyl, acyloxy, alkyloxycarbonyloxy, aryloxycarbonyloxy, cycloalkyl (including for example, cyclohexylcarbinol), cycloalkenyl, alkoxy, cycloalkoxy, aryl, heteroaryl, arylalkoxy carbonyl, alkoxy carbonylacyl, aminocarbonyl, aminocarboyloxy, azido, phenyl, cycloalkylacyl, alkylthio, arylthio, oxysulfonyl, carboxy, thio, sulfoxide, sulfone, sulfonate esters, thiocyano, boronic acids and esters, and halogenated alkyl including polyhalogenated alkyl or a combination thereof;
• and L is null or a linker comprising one or more R2,
• each R2 can be independently selected from the group consisting of hydrogen, halogen, nitro, amino, hydroxyl, cyano, optionally substituted C1-C24 alkyl, optionally substituted C2-C24 alkenyl, optionally substituted C2-C24 alkynyl, acyl, acyloxy, alkyloxycarbonyloxy, aryloxycarbonyloxy, cycloalkyl (including for example, cyclohexylcarbinol), cycloalkenyl, alkoxy, cycloalkoxy, aryl, heteroaryl, arylalkoxy carbonyl, alkoxy carbonylacyl, aminocarbonyl, aminocarboyloxy, azido, phenyl, cycloalkylacyl, alkylthio, arylthio, oxysulfonyl, carboxy, thio, sulfoxide, sulfone, sulfonate esters, thiocyano, boronic acids and esters, and halogenated alkyl including polyhalogenated alkyl, or a combination thereof, and
• rings A, B and/or C of formula I and II can each independently be aromatic, partially unsaturated or fully saturated.