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US 2016/0106690 A1Published application
Pain relief compositions, manufacture and uses
AssigneeAPI Genesis, LLC
InventorsDaniel BUCKS, Philip J. BIRBARA
Life of this patent
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Abstract
The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
Claims50
A composition comprising:
- i) 0.075-30% by weight of a TRPV1 selective agonist, and
- ii) 50-95% by weight of an analgesic agent comprising a) a topical salicylate and b) a TRPM8 agonist or a TRPV3 agonist, capable of solubilizing said TRPV1 selective agonist,
- wherein said composition has an amount of TRPV1 selective agonist sufficient to decrease the density of functional nociceptive nerve fibers when said composition is applied topically, and said composition has an amount of analgesic agent sufficient to eliminate or reduce the burning and/or stinging sensation or erythema created by the topical administration of the TRPV1 selective agonist.
A composition comprising:
- 0.075-30% by weight of a TRPV1 selective agonist, and
- 70-95% by weight of an analgesic agent capable of solubilizing said TRPV1 selective agonist,
- wherein said composition has an amount of TRPV1 selective agonist sufficient to decrease the density of functional nociceptive nerve fibers when said composition is applied topically, and said composition has an amount of analgesic agent sufficient to eliminate or reduce the burning and/or stinging sensation or erythema created by the topical administration of the TRPV1 selective agonist, and wherein said composition does not include turpentine oil.
A composition comprising:
- 70-95% by weight methyl salicylate and/or ethanol,
- 10-20% by weight menthol, and
- 10-20% by weight camphor, and optionally 0.5-5.0% by weight phenol,
- wherein the percentage by weight of the methyl salicylate, menthol, and camphor is greater than 70% of the composition.
1 more element
A composition comprising:
- a capsaicinoid,
- methyl salicylate and/or ethyl alcohol, and
- phenol,
- wherein the percentage by weight of the methyl salicylate and phenol is greater than 50% of the composition.
1 more element
A method of formulating a capsaicinoid liquid comprising:
- dissolving a capsaicinoid in methyl salicylate and/or ethanol to form a solution, and
- adding camphor and/or menthol to the solution.
A method of producing a topical formulation of capsaicin comprising:
- mixing a capsaicinoid and methyl salicylate and/or ethanol, and
- adding one or more of methyl salicylate, camphor and phenol.
Dependencies are inferred from the claim text.