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US 2016/0106685 A1Published application
Ciprofloxacin loaded diethylaminoethyl cellulose nanoparticles
OwnerMuhammad Akhyar Farrukh, Muhammad Rehan Gul +1inventors
InventorsMuhammad Akhyar Farrukh, Muhammad Rehan Gul, Muhammad Khaleeq-ur- Rahman
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Abstract
This invention reports ciprofloxacin (CIP)-encapsulated polymeric nanoparticles and its antibacterial potential with a variety of gram positive and gram negative pathogenic bacteria. CIP-encapsulated nanoparticles of diethylaminoethyl cellulose (DEA-EC) are prepared by the multiple emulsion solvent evaporation method. CIP-encapsulated nanoparticles showed superior effectiveness to inhibit the growth of bacteria in-vitro.
Claims6
A method of preparing ciprofloxacin loaded biodegradable polymeric nanoparticles comprising:
- a. preparing an oil phase of a nanoemulsion by dissolving a sufficient quantity of biodegradable biopolymer diethyl amino ethyl cellulose in ethyl acetate and stirring until emulsified;
- b. adding to solution (a) an aqueous solution of ciprofloxacin drop by drop and mixing using ultrasonic shaker;
- c. adding solution in step (b) to an aqueous solution of polyvinyl alcohol drop by drop until homogenous clear emulsion is formed;
- d. subjecting the solution in step (c) to ultracentrifugation;
- and,
- e. removing the sediment from step (d) and drying.
3 more elements
Dependencies are inferred from the claim text.