Liposomes Useful for Drug Delivery

A composition of a liposome having an interior space, said composition comprising the liposome in an aqueous medium, wherein the interior space:

• 1) is aqueous, 2) is separated from the aqueous medium by a membrane comprised of one or more lipids, and 3) contains sucrose octasulfate polyanion in the form of an acid or a salt of a taxane selected from the group consisting of:
• docetaxel and 2′-(diethylamino)-ester aminoacyl docetaxel prodrug.

A docetaxel prodrug liposome composition comprising sucrose octasulfate and a 2′-(diethylamino)-ester aminoacyl docetaxel prodrug encapsulated within a liposome formed from one or more lipids, wherein at least about 90% of the docetaxel prodrug is encapsulated within the liposome.

A method of administering docetaxel to a patient in need thereof, the method comprising the step of parenterally administering to the patient a docetaxel prodrug liposome in a first aqueous medium at a pH of about 5.0-6.5, the docetaxel prodrug liposome comprising cholesterol and a phospholipid and encapsulating a 2′-(diethylamino)-ester aminoacyl docetaxel prodrug in a second aqueous medium encapsulated within the docetaxel prodrug liposome at a pH lower than the pH of the first aqueous medium, wherein at least a portion of the docetaxel pro-drug is converted to docetaxel outside the liposome after parenteral delivery of the docetaxel prodrug liposome to the patient.