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US 2016/0106670 A1Published application
Novel Process
AssigneeGlaxosmithkline Biologicals SA
InventorsVinciane DE CUPERE, Vincent MANCUSO
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Abstract
The present invention provides a process for the production of an oil in water emulsion comprising the step of a) introducing an oil phase into a mixing device by applying a positive pressure in the oil phase containing tank.
Claims19
A process for the production of an oil in water emulsion comprising the steps of:
- a) introducing an oil phase into a mixing device by applying a positive pressure in the oil phase containing tank;
- b) introducing an aqueous phase into said mixing device by applying a positive pressure in the aqueous phase containing tank;
- c) mixing the oil and aqueous phases to form an oil in water emulsion;
- d) subjecting the oil in water emulsion of step c) to high pressure homogenization to form a submicron oil in water emulsion
- e) harvesting the submicron oil in water emulsion of step d) in a further tank;
- wherein the oil and/or aqueous phases are introduced into the mixing device by adjusting the pressure to about 2 to 6 bars and wherein the whole installation is submitted to a positive pressure.
3 more elements
Dependencies are inferred from the claim text.