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US 2016/0106667 A1Published application
Drug delivery devices for delivery of ocular therapeutic agents
AssigneeNovaer Holdings, Inc.
InventorsCasey Kopczynski, Cheng-Wen Lin, Chris Sutay
Life of this patent
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Abstract
Drug delivery devices comprising a non-bioabsorbable polymer structure configured to support a composition comprising an active agent. The devices include a plurality of portions fused together and a recess configured to support the composition. At least one of the portions includes an impermeable polymer and at least one other portion includes a rate-limiting water-permeable polymer. The rate-limiting water-permeable polymer allows for transportation of the active agent to an exterior of the device.
Claims10
-29. (canceled)
A device, comprising:
- a composition in the form of a matrix of an active agent and a non-water soluble polymer, wherein the active agent is selected from the group consisting of latanoprost free acid salt, travoprost free acid salt, bimatoprost free acid salt, and tafluprost free acid salt;
- a first polymer portion;
- a second polymer portion fused to the first polymer portion, the second polymer portion including a recess configured to support the composition;
- and
- a third polymer portion fused to the second polymer portion,
- wherein the total diameter of the device ranges from 3-5 mm, and
- wherein the device is configured to:
- (a) conform to a curvature of the eye,
- (b) yield an elution rate of 0.00025-0.0075 micrograms/hr of the active agent, and
- (c) release 70% to 90% of the active agent over a period of at least 30 days.
7 more elements
Dependencies are inferred from the claim text.