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US 2016/0103144 A1Published application
Blood based methods of assessing adolescent depression in a subject
AssigneeTrue Health Diagnostics, LLC
InventorsWilliam S. Harris, James V. Pottala, Andrew B. Christianson
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Abstract
The present invention provides blood based methods for assessing adolescent depression in a subject.
Claims11
A method for assessing adolescent depression in a subject, comprising
- (a) measuring an amount of one or more fatty acids in a tissue sample from a subject at risk of suffering from adolescent depression;
- (b) comparing the amount of the one or more fatty acids to a control;
- and
- (c) determining a probability that the adolescent subject has depression based on the comparison.
1 more element
A method for determining the fatty acid composition of a tissue membrane, comprising
- (a) methylating fatty acids in the tissue sample to produce fatty acid methyl esters (FAMEs) by treatment with a boron-trifluoride methanol solution;
- (b) extracting FAMEs from the tissue sample using a hexane solvent;
- (c) separating the FAMEs by gas chromatography in a fused silica capillary column;
- (d) determining retention times of the FAMEs in the column by means of a flame ionization detector (FID);
- and
- (e) comparing the retention time to a FAME standard;
- and
- (f) calculating FAME response factors for each FAME in the sample based on a FAME standard.
5 more elements
Dependencies are inferred from the claim text.