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OwnerYong Y. Lin, Shuren Ma +2inventors
InventorsYong Y. Lin, Shuren Ma, Gerard M. Turino, Toyonobu Usuki
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The present invention provides, inter alia, methods for measuring the amount of a marker of elastic fiber injury in a sample. The methods include contacting a sample with a compound of formula (1) and carrying out mass spectrometry on the sample containing the compound of formula (1). Also provided are methods of diagnosing whether a subject has a disease characterized by elastic fiber injury, a method for improving the accuracy and precision of mass spectroscopy analysis of a marker of elastic fiber injury, and kits for determining, by mass spectrometry, the amount of a marker of elastic fiber injury in a sample from a subject. Further provided are methods for preventing the progression of the effects associated with alpha-1 antitrypsin deficiency (AATD) in a subject with normal lung function.
A method of measuring the amount of a marker of elastic fiber injury selected from the group consisting of desmosine, isodesmosine, and a combination thereof in a sample, comprising contacting the sample with a compound of formula (1):
A method of diagnosing whether a subject has a disease characterized by an elastic fiber injury comprising:
A method of improving the accuracy and precision of mass spectroscopy analysis of a marker of elastic fiber injury in a sample, the marker being selected from the group consisting of desmosine, isodesmosine, and a combination thereof comprising
A kit for determining, by mass spectrometry, the amount of a marker of elastic fiber injury in a sample from a subject, the kit comprising a compound of formula (1):
A method for preventing the progression of the effects associated with alpha-1 antitrypsin deficiency (AATD) in a subject with normal lung function comprising
A method for detecting lung elastin degradation in a subject with normal lung function comprising measuring, by mass spectrometry, a marker of elastic fiber injury selected from the group consisting of desmosine, isodesmosine, and a combination thereof in a sample from the subject.
Dependencies are inferred from the claim text.