Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells
AssigneeGPB Scientific, LLC
InventorAnne R. Kopf-Sill
Life of this patent
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Abstract
The invention encompasses methods and devices for diagnosing, theranosing, or prognosing a condition in a patient by enriching a sample in rare cells. The devices can be a microfluidic device comprising an array of obstacles and one or more binding moieties. The devices and methods can allow for enrichment of cells based on size and affinity, recovery of cells in locations on the microfluidic device, release of cells from the microfluidic device, flow of sample through the microfluidic device, and retention of rare cells from a sample obtained from a patient having a condition.
Claims21
A microfluidic device comprising:
- an array of obstacles including a first subarray of obstacles and a second subarray of obstacles that are fluidly connected and positioned such that a fluid medium introduced to an inlet of the microfluidic device passes sequentially through the first subarray then the second subarray before exiting through an outlet of the microfluidic device;
- wherein the first subarray or the second subarray of obstacles is functionalized with one or more sets of one or more binding moieties.
A method for diagnosing cancer comprising enumerating one or more enriched circulating tumor cells and fragments thereof using a bright field microscope.
21-100. (canceled)
Dependencies are inferred from the claim text.