Neuroglioma Molecular Subtyping Gene Group and Use Thereof
AssigneeBeijing Normal University
InventorsXiaolong FAN, Yingyu SUN, Tao JIANG
Life of this patent
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Abstract
A set of gene groups for predicting or for the auxiliary prediction of the survival time prognosis of patients with neuroglioma consists of a PM gene group and an EM gene group with a total of 68 genes. A subtype marking gene group consisting of two major gene groups co-expressed with PDGFRA and EGFR can stably divide neuroglioma samples from different database sources into three specific subtypes, and can be applied to clinical diagnosis for neuroglioma and judging the survival time prognosis of patients with neuroglioma.
Claims9
A kit for predicting or for auxiliary prediction of survival time prognosis of a patient with neuroglioma, comprising an agent for measuring the expression level of each of genes of a PM gene group and an EM gene group in ex vivo sample from a neuroglioma patient to be identified, and a comparison card;
- the PM gene group consisting of following 39 genes:
- C10orf18, C1QL1, C1orf106, C9orf140, CACNG4, CHD7, CSNK1E, EIF4EBP2, ETV1, FAM5C, KLRC3, LIX1L, LOC283174, LPHN3, LPPR1, MARCKS, MEX3A, MMP16, MYT1, NAV1, NLGN1, NOVA1, NXPH1, OLIG1, OLIG2, PATZ1, PCGF2, PDGFRA, POLR2F, RFX7, SOX4, SOX6, SOX8, TACC2, TMCC1, TSHZ1, ZEB1, ZNF22, ZNF462;
- the EM gene group consisting of following 29 genes:
- ACSS3, CDKN2C, DENND2A, DMRTA2, EGFR, ELOVL2, HS3ST3B1, ITGB8, LFNG, NCOA3, NES, NFIA, PDGFA, PMS2P11, POU3F2, PRPF31, RNF180, SALL1, SEC61G, SEMA6D, SHOX2, SNX5, SOCS2, SOX9, TNFRSF19, TRIOBP, UHRF1, VAV3, ZNF558;
- and
- the comparison card recording that:
- if the ex vivo sample from the neuroglioma patient to be identified has an average expression level of the PM gene group greater than or equal to that of the EM gene group, the neuroglioma patient to be identified has a survival time prognosis over or optionally over 1.9 years;
- and
- if the ex vivo sample from the neuroglioma patient to be identified has an average expression level of the PM gene group less than that of the EM gene group, the neuroglioma patient to be identified has a survival time prognosis of no more than or optionally no more than 1.9 years.
A set of gene groups for predicting or for auxiliary prediction of survival time prognosis of a patient with neuroglioma, consisting of a PM gene group and an EM gene group, a total of 68 genes:
- the PM gene group consisting of following 39 genes:
- C10orf18, C1QL1, C1orf106, C9orf140, CACNG4, CHD7, CSNK1E, EIF4EBP2, ETV1, FAM5C, KLRC3, LIX1L, LOC283174, LPHN3, LPPR1, MARCKS, MEX3A, MMP16, MYT1, NAV1, NLGN1, NOVA1, NXPH1, OLIG1, OLIG2, PATZ1, PCGF2, PDGFRA, POLR2F, RFX7, SOX4, SOX6, SOX8, TACC2, TMCC1, TSHZ1, ZEB1, ZNF22, ZNF462;
- and
- the EM gene group consisting of following 29 genes:
- ACSS3, CDKN2C, DENND2A, DMRTA2, EGFR, ELOVL2, HS3ST3B1, ITGB8, LFNG, NCOA3, NES, NFIA, PDGFA, PMS2P11, POU3F2, PRPF31, RNF180, SALL1, SEC61G, SEMA6D, SHOX2, SNX5, SOCS2, SOX9, TNFRSF19, TRIOBP, UHRF1, VAV3, ZNF558.
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Dependencies are inferred from the claim text.